Cyclic AMP in prokaryotes

آدنوزین منوفسفات حلقوی ( Cyclic AMP )

The cyclic AMP pathway.

Cyclic adenosine 3′,5′-monophosphate (cAMP) was the first second messenger to be identified and plays fundamental roles in cellular responses to many hormones and neurotransmitters (Sutherland and Rall 1958). The intracellular levels of cAMP are regulated by the balance between the activities of two enzymes (see Fig. 1): adenylyl cyclase (AC) and cyclic nucleotide phosphodiesterase (PDE). Diffe...

Cyclic AMP signalling.

Cyclic adenosine 3′,5′-monophosphate (cAMP) was the first identified second messenger. A large number of studies during the past 30 years have elucidated the fundamental role of cAMP in the cellular response to many hormones and neurotransmitters. Although the main components in the cAMP-mediated signalling pathway are well known, recently new important players have been identified, which have ...

Cyclic AMP-induced conformational change of cyclic AMP receptor protein (CRP): intragenic suppressors of cyclic AMP-independent CRP mutations.

We isolated and characterized crp mutations in Escherichia coli that allow cyclic AMP (cAMP) receptor protein to function without cAMP. These mutants defined a region involved in the cAMP-induced allosteric change of cAMP receptor protein that is necessary for activation of the protein. Currently, we have isolated intragenic suppressors of the crp mutations. These crp (Sup) mutants require cAMP...

Cyclic AMP-induced p53 Destabilization is Independent of CREB in pre-B Acute Lymphoblastic Leukemia Cells

Elevated cAMP levels in B-cell precursor acute lymphoblastic leukemia (BCP-ALL) cells attenuate the doxorubicin-induced p53 accumulation and protect cells against apoptosis. cAMP responsive element binding protein (CREB) is a cAMP-stimulated transcription factor that regulates genes whose deregulated expression cooperatein oncogenesis. In the present study, we investigated the role of CREB on i...